The Oslo definitions for coeliac disease and related terms. Issue 1 (16th February 2012)

• Record Type: Journal Article
• Authors: Ludvigsson, Jonas F; Leffler, Daniel A; Bai, Julio C; Biagi, Federico; Fasano, Alessio; Green, Peter H R; Hadjivassiliou, Marios; Kaukinen, Katri; Kelly, Ciaran P; Leonard, Jonathan N; Lundin, Knut Erik Aslaksen; Murray, Joseph A; Sanders, David S; Walker, Marjorie M; Zingone, Fabiana; Ciacci, Carolina
• Is Part Of: Gut. Volume 62:Issue 1(2013)
• Page Start: 43
• Page End: 52
• Publication Date: 2012-02-16
• Subjects: Adult -- autoimmunity -- child -- coeliac -- gluten -- sensitivity -- intolerance -- coeliac disease -- paediatric gastroenterology -- epidemiology -- malabsorption -- antiendomysial antibodies -- gliadin immunology -- epithelial permeability -- tight junction -- diarrhoeal disease -- bacterial pathogenesis -- epithelial barrier -- intestinal permeability -- mucosal barrier -- small intestinal biopsy -- chemokines -- mucosal immunity -- bacterial enterotoxins -- bacterial infection -- achalasia -- small intestinal absorption -- gastrostomy -- gastrointestinal bleeding -- histopathology -- Helicobacter pylori -- HLA class II alleles -- inflammatory diseases -- irritable bowel syndrome; Gastroenterology -- Periodicals; 616.33
• DOI: 10.1136/gutjnl-2011-301346
• Languages: English
• ISSNs: 0017-5749

Abstract

Abstract : Objective: The literature suggests a lack of consensus on the use of terms related to coeliac disease (CD) and gluten. Design: A multidisciplinary task force of 16 physicians from seven countries used the electronic database PubMed to review the literature for CD-related terms up to January 2011. Teams of physicians then suggested a definition for each term, followed by feedback of these definitions through a web survey on definitions, discussions during a meeting in Oslo and phone conferences. In addition to 'CD', the following descriptors of CD were evaluated (in alphabetical order): asymptomatic, atypical, classical, latent, non-classical, overt, paediatric classical, potential, refractory, silent, subclinical, symptomatic, typical, CD serology, CD autoimmunity, genetically at risk of CD, dermatitis herpetiformis, gluten, gluten ataxia, gluten intolerance, gluten sensitivity and gliadin-specific antibodies. Results: CD was defined as 'a chronic small intestinal immune-mediated enteropathy precipitated by exposure to dietary gluten in genetically predisposed individuals'. Classical CD was defined as 'CD presenting with signs and symptoms of malabsorption. Diarrhoea, steatorrhoea, weight loss or growth failure is required.' 'Gluten-related disorders' is the suggested umbrella term for all diseases triggered by gluten and the term gluten intolerance should not to be used. Other definitions are presented in the paper. Conclusion: This paper presents the Oslo definitions for CD-related terms.