A randomised, double-blind, placebo-controlled phase IIB clinical trial of repeated application of gene therapy in patients with cystic fibrosis. Issue 11 (22nd March 2013)

• Record Type: Journal Article
• Authors: Alton, Eric W F W; Boyd, A Christopher; Cheng, Seng H; Cunningham, Steve; Davies, Jane C; Gill, Deborah R; Griesenbach, Uta; Higgins, Tracy; Hyde, Stephen C; Innes, J Alastair; Murray, Gordon D; Porteous, David J
• Is Part Of: Thorax. Volume 68:Issue 11(2013)
• Page Start: 1075
• Page End: 1077
• Publication Date: 2013-03-22
• Subjects: Cystic Fibrosis; Chest -- Diseases -- Periodicals; Thorax; Chest -- Diseases; Periodicals; Periodicals; 617.54
• DOI: 10.1136/thoraxjnl-2013-203309
• Languages: English
• ISSNs: 0040-6376

Abstract

Abstract : The UK Cystic Fibrosis Gene Therapy Consortium has been working towards clinical gene therapy for patients with cystic fibrosis for several years. We have recently embarked on a large, multi-dose clinical trial of a non-viral, liposome-based formulation powered for the first time to detect clinical benefit. The article describes the details of the protocol.