THU0620 Gender, Disease Activity, Anxiety and Depression Levels Are Related To The Levels of Fears of Patients with Rheumatoid Arthritis or Axial Spondyloarthritis: A Cross-Sectional Study of 672 Patients. (15th July 2016)

• Record Type: Journal Article
• Authors: Gossec, L.; Chauvin, P.; Hudry, C.; Poussière, M.; de Chalus, T.; Saulot, V.; Russo-Marie, F.; Joubert, J.M.; Saraux, A.; Berenbaum, F.
• Is Part Of: Annals of the rheumatic diseases. Volume 75(2016)Supplement 2
• Page Start: 417
• Page End: 418
• Publication Date: 2016-07-15
• Subjects: Rheumatism -- Periodicals; 616.723005
• DOI: 10.1136/annrheumdis-2016-eular.2151
• Languages: English
• ISSNs: 0003-4967

Abstract

Abstract : Background: Patients (pts) with rheumatoid arthritis (RA) and axial spondyloarthritis (axSpA) have personal fears related to their disease which can impact therapeutic strategy. 1 We previously reported high levels of fears in RA and axSpA pts in a French multicenter survey. 2 Objectives: To identify factors associated with high levels of fears in RA and axSpA pts. Methods: This national cross-sectional study was performed in 2014–2015 in France. 2 Rheumatologists recruited 6–20 pts with RA (ACR/EULAR criteria) or axSpA (ASAS criteria). Pts self-completed the "Opinions and fears of pts with chronic inflammatory rheumatism" (QOC-RIC) questionnaire 2 comprising 44 items including 23 questions on pt fears; each scored between 0–10 (10 = "totally agree"). Eighteen questions related to progression and consequences of the disease and 5 questions related to treatment. For each fear, descriptive analysis explored the percentage of pts with scores ≥7/10. A cluster analysis was run on the whole population to identify homogeneous groups (clusters) of pts according to their fears and beliefs (hierarchical ascendant classification). A multivariate multinomial logistic regression model using backward selection and multiple missing data imputation explored the variables (eg. epidemiological, socioeconomic, clinical) with p<0.05 on differences between clusters. Results: Overall, 672 pts recruited by 100 rheumatologists were analyzed (432 RA, 240 axSpA). For RA and axSpA pts respectively, 74.0% and 45.2% were female, average age was 58.3 (±13.1) and 47.0 (±13.2) years, and 77.3% and 72.7% were treated with biologics. Mean Disease Activity Score 28 (DAS28[ESR]) in RA pts was 2.64 (±1.24) and mean Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) in axSpA pts was 3.3 (±2.2). Four pt clusters were identified corresponding to very high (31.6%), high (21.9%), moderate (32.7%) or low (13.8%) levels of fears (Figure ). Variables related to the highest fear cluster were gender (female vs male; OR=2.38, p=0.013), high Pt Global Assessment of Disease Activity (PtGA [VAS]; >60 vs ≤30; OR=3.03, p=0.029), anxiety (HADS, anxiety score; >10 vs <8; OR=4.55, p<0.001) and depression (HADS, depression score; ≥8 vs <8; OR=3.23, p=0.011). Socioprofessional and family status did not have an associated p value <0.05 between populations with lowest and highest fears. Conclusions: Pts with the highest fears were most likely to be women with higher PtGA and anxiety/depression scores. Fears may reflect overall psychological distress in this population of pts and interventions to decrease these fears should be further assessed. References: Nestoriuc Y. Arthritis Care Res 2010;62:791–9; Gossec L. Ann Rheum Dis 2015;74(S2):323 Acknowledgement: The authors acknowledge Costello Medical Consulting, funded by UCB Pharma, for writing and editorial assistance. This study was funded by UCB Pharma and Arthritis Foundation Olivier Courtin. Disclosure of Interest: L. Gossec: None declared, P. Chauvin: None declared, C. Hudry: None declared, M. Poussière: None declared, T. de Chalus Employee of: UCB Pharma, V. Saulot: None declared, F. Russo-Marie: None declared, J. Joubert Employee of: UCB Pharma, A. Saraux: None declared, F. Berenbaum: None declared