Prolonged neutropenia after irinotecan-based chemotherapy in a child with polymorphisms of UGT1A1 and SLCO1B1. Issue 12 (15th July 2009)

• Record Type: Journal Article
• Authors: Sakaguchi, S; Garcia-Bournissen, F; Kim, R; Schwarz, U I; Nathan, P C; Ito, S
• Is Part Of: Archives of disease in childhood. Volume 94:Issue 12(2009)
• Page Start: 981
• Page End: 982
• Publication Date: 2009-07-15
• Subjects: Children -- Diseases -- Periodicals; Infants -- Diseases -- Periodicals; 618.920005
• DOI: 10.1136/adc.2009.163089
• Languages: English
• ISSNs: 0003-9888

Abstract

Abstract : Genetic polymorphisms of uridine diphosphate glucuronosyl transferase 1A1 ( UGT1A1 ), and SLCO1B1 coding organic anion-transporter polypeptide 1B1, are independent risk factors known to increase irinotecan toxicity in adults. Although combined occurrence of polymorphisms in these 2 genes is likely to influence susceptibility to irinotecan toxicity, data are scarce, especially in children. We report an 11-year-old female with severe and prolonged neutropenia after irinotecan-based chemotherapy. The patient's genotyping revealed polymorphisms in both UGT1A1 and SLCO1B1 . To our knowledge, this is the first case report of combined genotyping of both UGT1A1 and SLCO1B1 in a child with severe irinotecan toxicity.