Clinical characterisation of sensory neuropathy with anti-FGFR3 autoantibodies. Issue 1 (5th November 2019)

• Record Type: Journal Article
• Authors: Tholance, Yannick; Moritz, Christian Peter; Rosier, Carole; Ferraud, Karine; Lassablière, François; Reynaud-Federspiel, Evelyne; França Jr, Marcondes C; Martinez, Alberto R M; Camdessanché, Jean-Philippe; Antoine, Jean-Christophe
• Other Names: author non-byline.; Adams David author non-byline.; Cauquil Cécile author non-byline.; Attarian Shahram author non-byline.; Delmont Emilien author non-byline.; Blanchet-Fourcade Genevieve author non-byline.; Callias Céline author non-byline.; Cassereau Julien author non-byline.; Choumert Ariane author non-byline.; Clavelou Pierre author non-byline.; Créange Alain author non-byline.; Virgilio Gabriella Di author non-byline.; Echaniz-Laguna Andoni author non-byline.; Faucher Benoit author non-byline.; Galea Ian author non-byline.; Genestet Steeve author non-byline.; Guéguen Antoine author non-byline.; Ion Ioana M author non-byline.; Juntas-Morales Raul author non-byline.; Taieb Guillaume author non-byline.; Kuntzer Thierry author non-byline.; Lagrange Emmeline author non-byline.; Léger Jean-Marc author non-byline.; Stojkovic Tanya author non-byline.; Lepetit Maud author non-byline.; Magy Laurent author non-byline.; Mas Julie author non-byline.; Michaud Maud author non-byline.; Mouthon-Reignier Capucine author non-byline.; Neau Jean-Philippe author non-byline.; Ozsancak Canan author non-byline.; Péréon Yann author non-byline.; Perrotte Paul author non-byline.; Puma Angela author non-byline.; Rajabally Yusuf A author non-byline.; Rinaldi Simon author non-byline.; Rouaud Violaine author non-byline.; Sole Guilhem author non-byline.; Tard Céline author non-byline.; Vallet Anne-Evelyne author non-byline.; Vial Christophe author non-byline.;
• Is Part Of: Journal of neurology, neurosurgery and psychiatry. Volume 91:Issue 1(2020)
• Page Start: 49
• Page End: 57
• Publication Date: 2019-11-05
• Subjects: anti-FGFR3 autoantibodies -- autoimmune diseases -- fibroblast growth factor receptor 3 (FGFR3) -- sensory neuronopathies -- sensory neuropathies; Neurology -- Periodicals; Nervous system -- Surgery -- Periodicals; Psychiatry -- Periodicals; 616.8
• DOI: 10.1136/jnnp-2019-321849
• Languages: English
• ISSNs: 0022-3050

Abstract

Abstract : Objective: Sensory neuropathies (SNs) are often classified as idiopathic even if immunological mechanisms can be suspected. Antibodies against the intracellular domain of the fibroblast growth factor receptor 3 (FGFR3) possibly identify a subgroup of SN affecting mostly the dorsal root ganglion (DRG). The aim of this study was to identify the frequency of anti-FGFR3 antibodies and the associated clinical pattern in a large cohort of patients with SN. Methods: A prospective, multicentric, European and Brazilian study included adults with pure SN. Serum anti-FGRF3 antibodies were analysed by ELISA. Detailed clinical and paraclinical data were collected for each anti-FGFR3-positive patient and as control for anti-FGFR3-negative patients from the same centres ('center-matched'). Results: Sixty-five patients out of 426 (15%) had anti-FGFR3 antibodies, which were the only identified autoimmune markers in 43 patients (66%). The neuropathy was non-length dependent in 89% and classified as sensory neuronopathy in 64%, non-length-dependent small fibre neuropathy in 17% and other neuropathy in 19%. Specific clinical features occurred after 5–6 years of evolution including frequent paresthesia, predominant clinical and electrophysiological involvement of the lower limbs, and a less frequent mixed large and small fibre involvement. Brazilians had a higher frequency of anti-FGFR3 antibodies than Europeans (36% vs 13%, p<0.001), and a more frequent asymmetrical distribution of symptoms (OR 169, 95% CI 3.4 to 8424). Conclusions: Anti-FGFR3 antibodies occur in a subgroup of SN probably predominantly affecting the DRG. Differences between Europeans and Brazilians could suggest involvement of genetic or environmental factors.