Guidelines for the management of hereditary colorectal cancer from the British Society of Gastroenterology (BSG)/Association of Coloproctology of Great Britain and Ireland (ACPGBI)/United Kingdom Cancer Genetics Group (UKCGG). Issue 3 (28th November 2019)

• Record Type: Journal Article
• Authors: Monahan, Kevin J; Bradshaw, Nicola; Dolwani, Sunil; Desouza, Bianca; Dunlop, Malcolm G; East, James E; Ilyas, Mohammad; Kaur, Asha; Lalloo, Fiona; Latchford, Andrew; Rutter, Matthew D; Tomlinson, Ian; Thomas, Huw J W; Hill, James
• Other Names: author non-byline.; Seppälä Toni author non-byline.; Clark Sue author non-byline.; Faiz Omar author non-byline.; Balaguer Francesc author non-byline.; Leerdam Monique van author non-byline.; Gareth Evans D author non-byline.; Jover Rodrigo author non-byline.; Tischkowitz Marc author non-byline.; Hanson Helen author non-byline.; Gibson Sarah author non-byline.; Taylor Amy author non-byline.; Moeslein Gabreilla author non-byline.; Wagner Anja author non-byline.; Saurin JC author non-byline.; Smith Tracy author non-byline.; Ashford Jane author non-byline.; Martin Jennifer author non-byline.; Gunningham Jennifer author non-byline.; Cooper Mark author non-byline.
• Is Part Of: Gut. Volume 69:Issue 3(2020)
• Page Start: 411
• Page End: 444
• Publication Date: 2019-11-28
• Subjects: colorectal cancer -- genetic testing -- inherited cancers -- surveillance -- colorectal surgery; Gastroenterology -- Periodicals; 616.33
• DOI: 10.1136/gutjnl-2019-319915
• Languages: English
• ISSNs: 0017-5749

Abstract

Abstract : Heritable factors account for approximately 35% of colorectal cancer (CRC) risk, and almost 30% of the population in the UK have a family history of CRC. The quantification of an individual's lifetime risk of gastrointestinal cancer may incorporate clinical and molecular data, and depends on accurate phenotypic assessment and genetic diagnosis. In turn this may facilitate targeted risk-reducing interventions, including endoscopic surveillance, preventative surgery and chemoprophylaxis, which provide opportunities for cancer prevention. This guideline is an update from the 2010 British Society of Gastroenterology/Association of Coloproctology of Great Britain and Ireland (BSG/ACPGBI) guidelines for colorectal screening and surveillance in moderate and high-risk groups; however, this guideline is concerned specifically with people who have increased lifetime risk of CRC due to hereditary factors, including those with Lynch syndrome, polyposis or a family history of CRC. On this occasion we invited the UK Cancer Genetics Group (UKCGG), a subgroup within the British Society of Genetic Medicine (BSGM), as a partner to BSG and ACPGBI in the multidisciplinary guideline development process. We also invited external review through the Delphi process by members of the public as well as the steering committees of the European Hereditary Tumour Group (EHTG) and the European Society of Gastrointestinal Endoscopy (ESGE). A systematic review of 10 189 publications was undertaken to develop 67 evidence and expert opinion-based recommendations for the management of hereditary CRC risk. Ten research recommendations are also prioritised to inform clinical management of people at hereditary CRC risk.