Coronary microvascular dysfunction: a key step in the development of uraemic cardiomyopathy?. Issue 17 (25th June 2019)

• Record Type: Journal Article
• Authors: Radhakrishnan, Ashwin; Pickup, Luke C; Price, Anna M; Law, Jonathan P; Edwards, Nicola C; Steeds, Richard P; Ferro, Charles J; Townend, Jonathan N
• Is Part Of: Heart. Volume 105:Issue 17(2019)
• Page Start: 1302
• Page End: 1309
• Publication Date: 2019-06-25
• Subjects: myocardial disease; Heart -- Diseases -- Treatment -- Periodicals; Cardiology -- Periodicals; 616.12
• DOI: 10.1136/heartjnl-2019-315138
• Languages: English
• ISSNs: 1355-6037

Abstract

Abstract : The syndrome of uraemic cardiomyopathy, characterised by left ventricular hypertrophy, diffuse fibrosis and systolic and diastolic dysfunction, is common in chronic kidney disease and is associated with an increased risk of cardiovascular morbidity and mortality. The pathophysiological mechanisms leading to uraemic cardiomyopathy are not fully understood. We suggest that coronary microvascular dysfunction may be a key mediator in the development of uraemic cardiomyopathy, a phenomenon that is prevalent in other myocardial diseases that share phenotypical similarities with uraemic cardiomyopathy such as hypertrophic cardiomyopathy and heart failure with preserved ejection fraction. Here, we review the current understanding of uraemic cardiomyopathy, highlight different methods of assessing coronary microvascular function and evaluate the current evidence for coronary microvascular dysfunction in chronic kidney disease.