AB0326 The Influence of Long Permanent Remission and Low Disease Activity on the Functional and Radiological Outcomes of Rheumatoid Arthritis. (9th June 2015) - Ermakova, Y.A.
Abstract : Background: Disease activity is the main of the factors, which influence on the evolution of rheumatoid arthritis (RA). The timely supression of the disease activity and the remission/low activity support prevents the development of functional and structural disorders in patients with early RA. Objectives: To investigate the influence of long remission/low activity support on the functional and radiological outcomes. Methods: We used the data of long-term Russian project "RADICAL" (Early Arthritis: Diagnostic, Outcomes, Criterions, Aggressive Treatment). 200 patients with early RA (diagnosed for less than two year) according to American College of Rheumatology criteria included in the study from 2003 to 2007 (67, 5% RF (+); 57% ACCP (+), 86, 5% women, age of 49 [40-58]). Patients followed for 5 years. They were treated by DMARDs including the biologic therapy (24%) according the "tight-control" principle. The radiological investigation of hands and feet, DAS28, HAQ and functional class evaluated every 12 months. Results: From 1 to 5 years of follow-up the number of patients with permanent remission was 28 (group 1), the number of patients with remission/low activity – 26 (group 2), with permanent activity (group 3) – 26, with recurrent RA (group 4) – 120. After 5 years of follow-up HAQ >0, 5 has been verified in 7% (group 1), 23% (group 2), 100% (group 3), 62% (group 4), p<0, 001. SHS (M±σ) was 37, 93±18, 98, 35, 42±15, 11, 69, 84±38, 70 and 51, 45±30, 06, respectively, p<0, 001. Conclusions: Patients with long permanent remission and low disease activity will benefit with better functional ability and will have less radiological damage. Disclosure of Interest: None declared