AB1026 A Rare Case of Infantile Systemic Lupus Erythematosus in the First Year of Life and Successful Treatment with Hydroxychloroquine. (9th June 2015)

• Record Type: Journal Article
• Authors: Lutz, T.; Grulich-Henn, J.; Schneiderbauer, R.; Hadaschik, E.
• Is Part Of: Annals of the rheumatic diseases. Volume 74(2015)Supplement 2
• Page Start: 1241
• Page End: 1242
• Publication Date: 2015-06-09
• Subjects: Rheumatism -- Periodicals; 616.723005
• DOI: 10.1136/annrheumdis-2015-eular.4482
• Languages: English
• ISSNs: 0003-4967

Abstract

Abstract : Background: Infantile SLE is an extremely rare disease as underlined by the fact that there are only few publications in the literature (only 13 patients have been published until now). Objectives: Case report of a rare disease. Methods: We report on a female patient who developed infantile systemic lupus erythematosus (iSLE) during the first year of life. At the age of 8 months the child presented with dry cough, strained breathing and agitation at night. 2 months later she developed fever attacks and a skin rash localized on the cheeks in a butterfly shape as well as on the extremities. Based on the clinical symptoms, serological findings and the skin biopsy we diagnosed infantile systemic lupus erythematosus. Results: Because the skin rash was unresponsive to steroid therapy, we decided to start a systemic treatment with hydroxychloroquine which dramatically improved the skin symptoms and fever attacks. Since the beginning of the therapy the patient has not yet developed a relapse of disease or any other systemic symptoms. Conclusions: In conclusion, we present a rare case of infantile systemic lupus erythematosus. To our best knowledge we are the first to describe a successful treatment with systemic hydroxychloroquine in a patient with iSLE. Since the induced therapy with hydroxychloroquine the patient did not suffer from skin rash or other systemic symptoms any more. References: Zulian F, Pluchinotta F, Martini G et al. Severe clinical course of systemic lupus erythematosus in the first year of life. Lupus 2008; 17: 780-6. Pluchinotta FR, Schiavo B, Vittadello F et al. Distinctive clinical features of pediatric systemic lupus erythematosus in three different age classes. Lupus 2007; 16: 550-5. Disclosure of Interest: None declared