Association between alcohol exposure and the risk of amyotrophic lateral sclerosis in the Euro-MOTOR study. Issue 1 (3rd August 2018)

• Record Type: Journal Article
• Authors: D'Ovidio, Fabrizio; Rooney, James P K; Visser, Anne E; Manera, Umberto; Beghi, Ettore; Logroscino, Giancarlo; Vermeulen, Roel C H; Veldink, Jan Herman; van den Berg, Leonard H; Hardiman, Orla; Chiò, Adriano
• Other Names: author non-byline.; Zecca Chiara author non-byline.; Tortelli Rosanna author non-byline.; Pupillo Elisabetta author non-byline.; Comi Giancarlo author non-byline.; Riva Nilo author non-byline.; Lunetta Christian author non-byline.; Filosto Massimiliano author non-byline.; Sofia Cotelli Maria author non-byline.; Rinaldi Fabrizio author non-byline.; Guaita Maria Cristina author non-byline.; Perrone Patrizia author non-byline.; Diamanti Luca author non-byline.; Ferrarese Carlo author non-byline.; Tremolizzo Lucio author non-byline.; Maurizio Clerici Angelo author non-byline.; Mauri Marco author non-byline.; Bono Giorgio author non-byline.; Heverin Mark author non-byline.; Vajda Alice author non-byline.; O'Sullivan Meabhdh author non-byline.; Breen Nadia author non-byline.; Quinlan Emma author non-byline.; Kirby Emma author non-byline.; Kinsella Anna author non-byline.; Madden Caoifa author non-byline.; van der Kooi Anneke J author non-byline.; Raaphorst Joost author non-byline.; Ge Calvin author non-byline.; Casale Federico author non-byline.; Mazzini Letizia author non-byline.; Calvo Andrea author non-byline.; Canosa Antonio author non-byline.; Moglia Cristina author non-byline.; Bertuzzo Davide author non-byline.; Mazzini Letizia author non-byline.; Bersano Enrica author non-byline.; Gerardi Francesca author non-byline.; Chiveri Luca author non-byline.; Ceroni Mauro author non-byline.; Delodovici Maria Luisa author non-byline.; Chiara Zecca author non-byline.; Rosanna Tortelli author non-byline.; Elisabetta Pupillo author non-byline.; Giancarlo Comi author non-byline.; Nilo Riva author non-byline.; Christian Lunetta author non-byline.; Massimiliano Filosto author non-byline.; Maria Sofia Cotelli author non-byline.; Fabrizio Rinaldi author non-byline.; Maria Cristina Guaita author non-byline.; Patrizia Perrone author non-byline.; Luca Diamanti author non-byline.; Carlo Ferrarese author non-byline.; Lucio Tremolizzo author non-byline.; Angelo Maurizio Clerici author non-byline.; Marco Mauri author non-byline.; Giorgio Bono author non-byline.; Mark Heverin author non-byline.; Alice Vajda author non-byline.; Meabhdh O'Sullivan author non-byline.; Nadia Breen author non-byline.; Emma Quinlan author non-byline.; Emma Kirby author non-byline.; Anna Kinsella author non-byline.; Caoifa Madden author non-byline.; Anneke J van der Kooi author non-byline.; Joost Raaphorst author non-byline.; Calvin Ge author non-byline.; Federico Casale author non-byline.; Letizia Mazzini author non-byline.; Andrea Calvo author non-byline.; Antonio Canosa author non-byline.; Cristina Moglia author non-byline.; Davide Bertuzzo author non-byline.; Letizia Mazzini author non-byline.; Enrica Bersano author non-byline.;
• Is Part Of: Journal of neurology, neurosurgery and psychiatry. Volume 90:Issue 1(2019)
• Page Start: 11
• Page End: 19
• Publication Date: 2018-08-03
• Subjects: Neurology -- Periodicals; Nervous system -- Surgery -- Periodicals; Psychiatry -- Periodicals; 616.8
• DOI: 10.1136/jnnp-2018-318559
• Languages: English
• ISSNs: 0022-3050

Abstract

Abstract : Objectives: Several studies focused on the association between alcohol consumption and amyotrophic lateral sclerosis (ALS), although with inconsistent findings. Antioxidants may play a role since lyophilised red wine was found to prolong SOD1 mice lifespan. The aim of this international population-based case–control study performed in Ireland, The Netherlands and Italy was to assess the role of alcohol, and red wine in particular, in developing ALS. Methods: Euro-MOTOR is a case–control study where patients with incident ALS and controls matched for gender, age and area of residency were recruited in a population-based design. Logistic regression models adjusted for sex, age, cohort, education, leisure time physical activity, smoking, heart problems, hypertension, stroke, cholesterol and diabetes were performed. Results: 1557 patients with ALS and 2922 controls were enrolled in the study. Exposure to alcohol drinking was not significantly associated with ALS risk. A stratified analysis of exposure to alcohol by cohort revealed significant ORs in The Netherlands and in Apulia, with opposite directions (respectively 0.68 and 2.38). With regard to red wine consumption, only in Apulia the double-fold increased risk (OR 2.53) remained significant. A decreased risk was found for current alcohol drinkers (OR 0.83), while a significantly increased risk was detected among former drinkers (OR 1.63). Analysis of cumulative exposure to alcohol revealed no significant associations with ALS risk. Conclusion: With few exceptions, no significant association was found between alcohol consumption and ALS. The study of the association between alcohol and ALS requires a thorough exploration, especially considering the role of different type of alcoholic beverages.