Myelopathy in neonatal and infantile lupus erythematosus. Issue 7 (July 1987)

• Record Type: Journal Article
• Authors: Kaye, E M; Butler, I J; Conley, S
• Is Part Of: Journal of neurology, neurosurgery and psychiatry. Volume 50:Issue 7(1987)
• Page Start: 923
• Page End: 926
• Publication Date: 1987-07
• Subjects: Neurology -- Periodicals; Nervous system -- Surgery -- Periodicals; Psychiatry -- Periodicals; 616.8
• DOI: 10.1136/jnnp.50.7.923
• Languages: English
• ISSNs: 0022-3050

Abstract

Abstract : Two children with lupus erythematosus and myelopathy were studied. The first child developed the neonatal lupus erythematosus syndrome associated with transplacentally acquired anti-Ro/SSA antibodies. The cutaneous manifestations of neonatal lupus erythematosus disappeared but a residual myelopathy was confirmed at 16 months of age. The second child developed cutaneous lupus erythematosus at 3 months of age associated with a total deficiency of the Clr component of complement. A myelopathy and mesangial glomerulonephritis developed at 2 years of age which required treatment with corticosteroids. These two children with CNS lupus erythematosus, one associated with transplacentally acquired antibodies and the other associated with a complement deficiency, may suggest an immune-mediated mechanism for the pathogenesis of myelopathy in childhood lupus erythematosus.