Volumetric Markers of Body Composition May Improve Personalized Prediction of Major Arterial Bleeding After Pelvic Fracture: A Secondary Analysis of the Baltimore CT Prediction Model Cohort. Issue 4 (November 2021)

• Record Type: Journal Article
• Authors: Dreizin, David; Rosales, Remberto; Li, Guang; Syed, Hassan; Chen, Rong
• Is Part Of: Canadian Association of Radiologists journal. Volume 72:Issue 4(2021)
• Page Start: 854
• Page End: 861
• Publication Date: 2021-11
• Subjects: body composition biomarkers -- quantitative imaging -- CT -- pelvic fractures -- multivariable modeling -- personalized prediction -- precision diagnostics; Radiology, Medical -- Periodicals; Radiology, Medical -- Canada -- Periodicals; 616.0757
• DOI: 10.1177/0846537120952508
• Languages: English
• ISSNs: 0846-5371

Abstract

The Baltimore computed tomography (CT) prediction model for bleeding pelvic fractures is a multivariable decision tool that predicts angiopositivity from pelvic hematoma volume, active arterial bleeding, fracture patterns, and atherosclerosis. We hypothesized that quantitative markers of body composition and frailty could further improve model performance. Methods: This work is a retrospective secondary analysis of a single institution cohort used in the development of the Baltimore CT prediction model. The cohort includes 115 consecutive patients that underwent admission contrast-enhanced CT of the abdomen and pelvis for blunt trauma with pelvic ring disruption followed by conventional angiography. Major arterial injury requiring angioembolization served as the outcome variable. Angioembolization was required in 73/115 patients (63% of the cohort). Average age was 46.9 years (±SD 20.4). Body composition measurements were determined as 2-dimensional (2D) or 3-dimensional (3D) parameters and included mid-L3 trabecular bone attenuation, abdominal visceral fat area or volume, and percent muscle fat fraction (as a marker of sarcopenia) measured using segmentation and histogram analysis. Results: Models incorporating 2D (Model B) or 3D markers (model C) of body composition showed improvement over the original Baltimore model (model A) in all parameters of performance, quality, and fit (area under the receiver-operating curve [AUC], Akaike information criterion, Brier score, Hosmer-Lemeshow test, and adjusted-R2). Area under the receiver-operating curve increased from 0.83 (A), to 0.86 (B), and 0.88 (C). The greatest improvement was seen with 3D parameters. Conclusion: Once automated, quantitative visualization tools providing "free" 3D body composition information can be expected to improve personalized precision diagnostics, outcome prediction, and decision support in patients with bleeding pelvic fractures.