Familial extrapyramidal disease with peripheral neuropathy. Issue 4 (April 1982)

• Record Type: Journal Article
• Authors: Byrne, E; Thomas, P K; Zilkha, K J
• Is Part Of: Journal of neurology, neurosurgery and psychiatry. Volume 45:Issue 4(1982)
• Page Start: 372
• Page End: 374
• Publication Date: 1982-04
• Subjects: Neurology -- Periodicals; Nervous system -- Surgery -- Periodicals; Psychiatry -- Periodicals; 616.8
• DOI: 10.1136/jnnp.45.4.372
• Languages: English
• ISSNs: 0022-3050

Abstract

Abstract : A family is presented in which 10 members over three generations developed a Parkinsonian syndrome. Two siblings had additional clinical and electrophysiological evidence of an associated peripheral neuropathy and sural nerve biopsy in one case revealed axonal loss. This is the third family reported in the literature in which an extrapyramidal syndrome is associated with neuropathy, but differs from earlier reports in that neuropathic involvement was due to axonal degeneration rather than segmental demyelination.