One-year outcomes in a multicentre cohort study of incident rare diffuse parenchymal lung disease in children (ChILD). Issue 2 (20th November 2019)

• Record Type: Journal Article
• Authors: Cunningham, Steve; Graham, Catriona; MacLean, Morag; Aurora, Paul; Ashworth, Michael; Barbato, Angelo; Calder, Alistair; Carlens, Julia; Clement, Annick; Hengst, Meike; Kammer, Birgit; Kiper, Nural; Krenke, Katarzyna; Kronfeld, Kai; Lange, Joanna; Ley-Zaporozhan, Julia; Nicholson, Andrew G; Reu, Simone; Wesselak, Traudl; Wetzke, Martin; Bush, Andrew; Schwerk, Nicolaus; Griese, Matthias
• Other Names: author non-byline.; Bhatt Jayesh author non-byline.; Buchvald Frederik author non-byline.; Cobanoglu Nazan author non-byline.; Child Fran author non-byline.; Chinedu Nwokoro author non-byline.; Donato Leonard author non-byline.; Epaud Ralph author non-byline.; Escribano Ampara author non-byline.; Freihorst Achim author non-byline.; Gupta Atul author non-byline.; Guy Emma author non-byline.; Hübner Tobias author non-byline.; Kind-Jugend Petra Kaiser-Labusch author non-byline.; Lex Christiane author non-byline.; Mayell Sarah author non-byline.; Moss Samantha author non-byline.; Emiralioglu Nagehan author non-byline.; Nährlich Lutz author non-byline.; Nathan Nadia author non-byline.; O'Reilly Ruth author non-byline.; Regamey Nicolas author non-byline.; Rochat Isabelle author non-byline.; Rosewich Martin author non-byline.; Sismanlar Tugbu author non-byline.; Snijders Deborah author non-byline.; Stehling Florian author non-byline.
• Is Part Of: Thorax. Volume 75:Issue 2(2020)
• Page Start: 172
• Page End: 175
• Publication Date: 2019-11-20
• Subjects: Interstitial lung disease in Children -- mortality -- ventilation -- oxygen saturation; Chest -- Diseases -- Periodicals; Thorax; Chest -- Diseases; Periodicals; Periodicals; 617.54
• DOI: 10.1136/thoraxjnl-2019-213217
• Languages: English
• ISSNs: 0040-6376

Abstract

Abstract : We performed a prospective, observational, cohort study of children newly diagnosed with children's interstitial lung disease (ChILD), with structured follow-up at 4, 8, 12 weeks and 6 and 12 months. 127 children, median age 0.9 (IQR 0.3–7.9) years had dyspnoea (68%, 69/102), tachypnoea (75%, 77/103) and low oxygen saturation (SpO2 ) median 92% (IQR 88–96). Death (n=20, 16%) was the most common in those <6 months of age with SpO2 <94% and developmental/surfactant disorders. We report for the first time that ChILD survivors improved multiple clinical parameters within 8–12 weeks of diagnosis. These data can inform family discussions and support clinical trial measurements.