Multicentre, cross-cultural, population-based, case–control study of physical activity as risk factor for amyotrophic lateral sclerosis. Issue 8 (23rd April 2018)

• Record Type: Journal Article
• Authors: Visser, Anne E; Rooney, James P K; D'Ovidio, Fabrizio; Westeneng, Henk-Jan; Vermeulen, Roel C H; Beghi, Ettore; Chiò, Adriano; Logroscino, Giancarlo; Hardiman, Orla; Veldink, Jan H; van den Berg, Leonard H
• Other Names: author non-byline.; Bru-no Andrea author non-byline.; Fanti Carlo De author non-byline.; Fascendini Sara author non-byline.; Tomasoni Angela author non-byline.; Arnaboldi Marco author non-byline.; Valsecchi Manuela author non-byline.; Moleri Massimo author non-byline.; Poloni Marco author non-byline.; Alimonti Dario author non-byline.; Tagliavini Fabrizio author non-byline.; VeronicaRedaelli author non-byline.; Fede Giuseppe Di author non-byline.; Bizzozero Ilaria author non-byline.; Prioni Sara author non-byline.; Van der kooi Anneke J author non-byline.; Raaphorst Joost author non-byline.; Calvo Andrea author non-byline.; Moglia Cristina author non-byline.; Casale Federico author non-byline.; Canosa Antonio author non-byline.; Manera Umberto author non-byline.; Bertuzzo Davide author non-byline.; Mazzini Letizia author non-byline.; Bersano Enrica author non-byline.; Heverin Mark author non-byline.; Vadja Alice author non-byline.; Pupillo Elisabetta author non-byline.; Giancarlo Comi author non-byline.; Lunetta Christian author non-byline.; Gerardi Francesca author non-byline.; Filosto Massimiliano author non-byline.; Cotelli Maria Sofia author non-byline.; Rinaldi Fabrizio author non-byline.; Chiveri Luca author non-byline.; Guaita Maria Cristina author non-byline.; Perrone Patrizia author non-byline.; Mauro Ceroni author non-byline.; Diamanti Luca author non-byline.; Ferrarese Carlo author non-byline.; Tremolizzo Lucio author non-byline.; Delodovici Maria Luisa author non-byline.; Bono Giorgio author non-byline.; Zecca Chiara author non-byline.; Tortelli Rosanna author non-byline.;
• Is Part Of: Journal of neurology, neurosurgery and psychiatry. Volume 89:Issue 8(2018)
• Page Start: 797
• Page End: 803
• Publication Date: 2018-04-23
• Subjects: Neurology -- Periodicals; Nervous system -- Surgery -- Periodicals; Psychiatry -- Periodicals; 616.8
• DOI: 10.1136/jnnp-2017-317724
• Languages: English
• ISSNs: 0022-3050

Abstract

Abstract : Objective: To investigate the association between physical activity (PA) and amyotrophic lateral sclerosis (ALS) in population-based case–control studies in three European countries using a validated and harmonised questionnaire. Methods: Patients with incident ALS and controls were recruited from five population-based registers in The Netherlands, Ireland and Italy. Demographic and data regarding educational level, smoking, alcohol habits and lifetime PA levels in both leisure and work time were gathered by questionnaire, and quantified using metabolic equivalent of task scores. Logistic regression models adjusting for PA-related factors were used to determine the association between PA and ALS risk, and forest plots were used to visualise heterogeneity between regions. Results: 1557 patients and 2922 controls were included. We found a linear association between ALS and PA in leisure time (OR 1.07, P=0.01) and occupational activities (OR 1.06, P<0.001), and all activities combined (OR 1.06, P<0.001), with some heterogeneity between regions: the most evident association was seen in the Irish and Italian cohorts. After adjustment for other occupational exposures or exclusion of patients with a C9orf72 mutation, the ORs remained similar. Conclusion: We provide new class I evidence for a positive association between PA and risk of ALS in a large multicentre study using harmonised methodology to objectively quantify PA levels, with some suggestions for population differences.