Prion Protein Antagonists Rescue Alzheimer's Amyloid-β-Related Cognitive Deficits. Issue 2 (February 2019)

• Record Type: Journal Article
• Authors: Sagare, Abhay P.; Sweeney, Melanie D.; Nelson, Amy R.; Zhao, Zhen; Zlokovic, Berislav V.
• Is Part Of: Trends in molecular medicine. Volume 25:Issue 2(2019)
• Page Start: 74
• Page End: 76
• Publication Date: 2019-02
• Subjects: cellular prion protein -- Alzheimer's disease -- amyloid-β oligomers -- antagonist -- cognition; Molecular biology -- Periodicals; Pathology, Molecular -- Periodicals; Physiology, Pathological -- Periodicals; 572.8
• DOI: 10.1016/j.molmed.2019.01.001
• Languages: English
• ISSNs: 1471-4914

Abstract

Abstract : Recent studies revealed that cellular prion protein on neurons bind Alzheimer's amyloid-β oligomers, causing neurotoxic effects. A new article in Cell Reports by Gunther and colleagues ( Cell Rep . 2019; 26:145–158) shows that an orally administered cellular prion protein antagonist can rescue synaptic and cognitive deficits in Alzheimer's mice overexpressing amyloid-β.