Elucidation of structural abnormalities of the X chromosome using fluorescence in situ hybridisation with a Y chromosome painting probe. Issue 3 (March 1994)

• Record Type: Journal Article
• Authors: Howell, R T; Millener, R; Thorne, S; O'Loughlin, J; Brassey, J; McDermott, A
• Is Part Of: Journal of medical genetics. Volume 31:Issue 3(1994)
• Page Start: 206
• Page End: 208
• Publication Date: 1994-03
• Subjects: Medical genetics -- Periodicals; 616.042
• DOI: 10.1136/jmg.31.3.206
• Languages: English
• ISSNs: 1468-6244

Abstract

Abstract : Particular regions of the X and Y chromosomes share DNA sequence homology to the extent that cross hybridisation occurs. Thus, chromosome painting with a whole Y chromosome probe consistently results in fluorescence on specific regions of the X chromosome as well as the complete Y chromosome. This phenomenon has been exploited to elucidate the structure of unusual X chromosome rearrangements, without Y involvement, in two females.