BRCA1 Immunohistochemical Staining as a Prognostic Indicator in Uterine Serous Carcinoma. Issue 1 (1st January 2013)

• Record Type: Journal Article
• Authors: Beirne, James P.; Quinn, Jennifer E.; Maxwell, Perry; Kalloger, Steve E.; McAlpine, Jessica; Gilks, C. Blake; Harley, Ian J. G.; McCluggage, W. Glenn
• Is Part Of: International journal of gynecological cancer. Volume 23:Issue 1(2013)
• Page Start: 113
• Page End: 118
• Publication Date: 2013-01-01
• Subjects: BRCA1 -- Immunohistochemistry -- Uterine serous carcinoma -- Prognosis; Generative organs, Female -- Cancer -- Periodicals; 616.99465
• DOI: 10.1097/IGC.0b013e3182798188
• Languages: English
• ISSNs: 1048-891X

Abstract

Abstract : Objectives: The objective of this study was to investigate the relationship between BRCA1 protein expression, as determined by immunohistochemistry, and clinical outcome in uterine serous carcinoma (USC). Methods: A tissue microarray containing duplicate cores of 73 cases of USC was immunohistochemically stained with mouse anti-BRCA1 (Ab-1) mouse monoclonal (MS110) antibody. The cores were scored in a semiquantitative manner evaluating both the distribution and intensity of nuclear staining. BRCA1 protein expression was correlated with progression-free survival. Results: Seventy-two of 73 cases were assessable, and there was a statistically significant decreased progression-free survival for those cases exhibiting tumor cell nuclei staining of 76% or greater ( P = 0.0023). Conclusions: Our study illustrates that a low level of BRCA1 protein expression is a favorable prognostic indicator in USC, similar to what is observed in high-grade serous ovarian carcinoma. Further studies should focus on the BRCA1 status of USCs at a molecular level and also investigate whether BRCA1 protein expression is associated with response to chemotherapy in USC.