Localisation of malignant glioma by a radiolabelled human monoclonal antibody. Issue 5 (May 1983)

• Record Type: Journal Article
• Authors: Phillips, J; Alderson, T; Sikora, K; Watson, J
• Is Part Of: Journal of neurology, neurosurgery and psychiatry. Volume 46:Issue 5(1983)
• Page Start: 388
• Page End: 392
• Publication Date: 1983-05
• Subjects: Neurology -- Periodicals; Nervous system -- Surgery -- Periodicals; Psychiatry -- Periodicals; 616.8
• DOI: 10.1136/jnnp.46.5.388
• Languages: English
• ISSNs: 0022-3050

Abstract

Abstract : Human monoclonal antibodies were produced by fusing intratumoral lymphocytes from patients with malignant gliomas with a human myeloma line. One antibody was selected for further study after screening for binding activity to glioma cell lines. The patient from whom it was derived developed recurrent glioma. 1 mg of antibody was purified, radiolabelled with 131I, and administered intravenously. The distribution of antibody was determined in the blood, CSF and tumour cyst fluid and compared with that of a control human monoclonal immunoglobulin. Antibody localisation in the tumour was observed and confirmed by external scintiscanning.