Prenatal diagnosis of beta-thalassaemia by fetal red cell concentration with anti-AB serum. Issue 5 (October 1979)

• Record Type: Journal Article
• Authors: Furbetta, M; Valenti, C; Ximenes, A; Angius, A; Tuveri, T; Fioretti, P; Cao, A
• Is Part Of: Journal of medical genetics. Volume 16:Issue 5(1979)
• Page Start: 366
• Page End: 368
• Publication Date: 1979-10
• Subjects: Medical genetics -- Periodicals; 616.042
• DOI: 10.1136/jmg.16.5.366
• Languages: English
• ISSNs: 1468-6244

Abstract

Abstract : Prenatal diagnosis by globin chain synthesis analysis on fetal blood samples obtained by placental aspiration was performed in two pregnancies at risk for beta-thalassaemia. Since both fathers had blood group AB, and both mothers had group O, fetal red cell concentration from maternal-fetal mixtures was obtained with the aid of anti-AB serum. With this approach it was possible to carry out globin chain synthesis analysis with very small amounts of fetal blood. Heterozygous and normal genotypes were ascertained and confirmed after birth.