Dopamine receptors and sleep induction in man. Issue 5 (May 1979)

• Record Type: Journal Article
• Authors: Bassi, S; Albizzati, M G; Frattola, L; Passerini, D; Trabucchi, M
• Is Part Of: Journal of neurology, neurosurgery and psychiatry. Volume 42:Issue 5(1979)
• Page Start: 458
• Page End: 460
• Publication Date: 1979-05
• Subjects: Neurology -- Periodicals; Nervous system -- Surgery -- Periodicals; Psychiatry -- Periodicals; 616.8
• DOI: 10.1136/jnnp.42.5.458
• Languages: English
• ISSNs: 0022-3050

Abstract

Abstract : Sleep induction has been studied in humans after the administration of apomorphine, a direct stimulant of the central dopaminergic system. The drug induced sleep and vomiting in healthy volunteers while it had no significant effect on 10 Parkinsonism patients treated for a long period with L-dopa. Apomorphine given to a group of Parkinsonism patients not receiving any specific treatment, and with a lower degree of disease severity, induced vomiting and sleep with a pattern similar to that in healthy subjects. A relationship between the dopaminergic system and sleep induction is suggested.