Insertion/Deletion Polymorphism of the Angiotensin I-Converting Enzyme Gene in Patients with Breast Cancer and Effects on Prognostic Factors. (1st July 2007)

• Record Type: Journal Article
• Authors: Yaren, Arzu; Turgut, Sebahat; Kursunluoglu, Raziye; Oztop, Ilhan; Turgut, Gunfer; Degirmencioglu, Serkan; Kelten, Canan; Erdem, Ergun
• Is Part Of: Journal of investigative medicine. Volume 55:Number 5(2007)
• Page Start: 255
• Page End: 261
• Publication Date: 2007-07-01
• Subjects: angiotensin-converting enzyyme gene polymorphism -- breast cancer -- prognostic factors; Clinical medicine -- Periodicals; Medicine -- Research -- Periodicals; Medicine; Research -- United States; Clinical medicine; Medicine -- Research; Periodicals; 616.075
• DOI: 10.2310/6650.2007.00006
• Languages: English
• ISSNs: 1081-5589

Abstract

Abstract : The aims of the present study were to investigate the distribution of the insertion/deletion (I/D) polymorphism of the angiotensin-converting enzyme (ACE) gene in breast cancer patients and the association between ACE genotypes and clinicopathologic features, as well as their effects on prognosis. We assessed the I/D polymophism of the ACE gene by using polymerase chain reaction from peripheral blood in breast cancer and healthy age-matched women. The clinicopathologic parameters of breast cancer patients were obtained from medical records. Of the 57 patients, 31 (54.4%) had DD, 24 (42.1%) had ID, and 2 (3.5%) had II genotypes. In control subjects, 33 (63.5%) had DD, 12 (23.1%) had ID, and 7 (13.4%) had II genotypes. The ID genotype was seen more commonly in breast cancer patients ( p = .03). When the combination of ID and II genotypes was used as a reference group, the DD genotype was associated with negative hormone receptor status ( p = .003), tumor size ( p = .054), and lymph node involvement ( p = .07) but not histologic high grade and c- erb B2 overexpression. These results suggest that the DD genotype may accompany poor prognostic factors and influence the tumor course.