Amnesic syndrome after theophylline associated seizures: iatrogenic brain injury. Issue 5 (May 1994)

• Record Type: Journal Article
• Authors: O'Riordan, J I; Hutchinson, J; FitzGerald, M X; Hutchinson, M
• Is Part Of: Journal of neurology, neurosurgery and psychiatry. Volume 57:Issue 5(1994)
• Page Start: 643
• Page End: 645
• Publication Date: 1994-05
• Subjects: Neurology -- Periodicals; Nervous system -- Surgery -- Periodicals; Psychiatry -- Periodicals; 616.8
• DOI: 10.1136/jnnp.57.5.643
• Languages: English
• ISSNs: 0022-3050

Abstract

Abstract : Two patients developed a disabling amnesic syndrome after seizures associated with oral theophylline treatment. Such seizures are more likely in the elderly, in the presence of pre-existing neurological disease, and when theophylline is given with certain antibiotics and cimetidine. The mechanism of neuronal injury may be by the excessive release of endogenous excitotoxic glutamate.