Dominantly inherited cleft lip and palate in two families. Issue 6 (June 1989)

• Record Type: Journal Article
• Authors: Temple, K; Calvert, M; Plint, D; Thompson, E; Pembrey, M
• Is Part Of: Journal of medical genetics. Volume 26:Issue 6(1989)
• Page Start: 386
• Page End: 389
• Publication Date: 1989-06
• Subjects: Medical genetics -- Periodicals; 616.042
• DOI: 10.1136/jmg.26.6.386
• Languages: English
• ISSNs: 1468-6244

Abstract

Abstract : Two families with non-syndromic cleft lip and cleft palate are described. The linear pattern of inheritance through several generations is difficult to explain by conventional multifactorial models. The pedigrees strengthen the suggestion that a dominantly inherited mutation exists with a major influence on clefting of the lip and palate alone.