The cut-off value of impaired fasting glucose should be lower: Based on the associations of fasting blood glucose with blood lipids. Issue 2 (April 2020)

• Record Type: Journal Article
• Authors: Mengzi, Sun; Min, Wang; Chong, Sun; Pingping, Zheng; Yaogai, Lv; Liyuan, Pu; Shuo, Li; Yan, Yao; Lina, Jin
• Is Part Of: Primary care diabetes. Volume 14:Issue 2(2020)
• Page Start: 147
• Page End: 153
• Publication Date: 2020-04
• Subjects: Blood lipids -- Cut-off value -- Impaired fasting glucose -- Lamba-Mu-Sigma method -- Generalized additive models; Diabetes -- Periodicals; 616.462
• DOI: 10.1016/j.pcd.2019.07.004
• Languages: English
• ISSNs: 1751-9918

Abstract

Abstract: Objective: The previous study served impaired fasting glucose (IFG), a pre-diabetic state which was much greater than that of diabetic patients, have reached no consensus on its cut-off value. In this study, we aimed to explore the cut-off value of IFG via the associations of blood lipids with fasting plasma glucose (FPG). Design: A cross-sectional study in Jilin province, China, 2012. Sample: 13, 093 participants aged 18–79 years in Jilin province were involved in the study. The Lamba-Mu-Sigma (LMS) method and generalized additive model (GAM) were used to explore the associations of different levels of FPG and blood lipids. Results: The distributions of FPG, triglyceride (TG) and high-density lipoprotein cholesterol (HDL-c) were significantly different by gender ( p < 0.01). In general, both LMS and GAM results showed that the TG and HDL-c curves had a steeper tendency when the FPG was greater than 6.0 mmol/L. Conclusion: FPG was positively associated with TG while negatively associated with HDL-c, and the associations were stronger in females. The cut-off value of IFG was suggested to be 6.0 mmol/L.