Bamboo-shaving polysaccharide protects against high-diet induced obesity and modulates the gut microbiota of mice. (October 2018)

• Record Type: Journal Article
• Authors: Chen, Yufeng; Jin, Lu; Li, Yunhong; Xia, Guobin; Chen, Chun; Zhang, Ying
• Is Part Of: Journal of functional foods. Volume 49(2018)
• Page Start: 20
• Page End: 31
• Publication Date: 2018-10
• Subjects: Bamboo-shaving polysaccharide (BSP) -- Prebiotic -- Gut microbiota -- Inflammation -- Obesity -- Insulin resistance; BSP bamboo-shaving polysaccharide -- IL interleukin -- TNF-α tumor necrosis factor alpha -- MCP-1 monocyte chemoattractant protein-1 -- LPS lipopolysaccaride -- SCFAs short chain fatty acids -- NC normal chow diet -- HFD high fat diet -- T-CHO total cholesterol -- TG triacylglycerol -- HDL-C high density lipoprotein-cholesterol -- LDL-C low density lipoprotein-cholesterol -- FFA free fatty acid -- H&E Hematoxylin-Eosin -- cDNA complementary DNA -- OTUs operational taxonomic units -- ITT insulin tolerance test -- GTT glucose tolerance test -- AUC area under curve -- Pcoa principal coordinate analysis; Functional foods -- Analysis -- Periodicals; Food -- Biotechnology -- Periodicals; Nutrition -- Periodicals; 613.2
• DOI: 10.1016/j.jff.2018.08.015
• Languages: English
• ISSNs: 1756-4646

Abstract

Graphical abstract: Highlights: Bamboo-shaving polysaccharide (BSP) relieves high fat diet-induced obesity. BSP improves serum lipid profile and insulin sensitivity in obese mice. BSP reduces pro-inflammatory cytokines and LPS level in obese mice. BSP alters the diversity and composition of the gut microbiota in obese mice. Abstract: Increasing evidence has shown that gut microbiota plays a critical role in regulating pathogenesis of low-grade inflammation and obesity. Bamboo-shaving polysaccharide (BSP, purity: 80–85%, Mw ≈ 10, 000 g/mol) is well known for its immunomodulatory capacity. However, no study has previously investigated the anti-obesity activity of BSP. After high fat diet-fed mice were treated with BSP for 8 weeks, we showed that BSP not only improved community richness and diversity of gut microbiota, but also regulated the composition of gut microbiota. Specifically, mice treated with BSP showed lower ratio of Firmicutes / Bacteroidetes, lower relative abundance of harmful bacteria ( Enterobacter and Desulfovibrio ) and higher relative abundance of beneficial bacteria ( Akkermansia muciniphila and Lactobacillus ). Moreover, BSP meliorated intestinal barrier integrity, reduced low-grade inflammation, improved lipid metabolism and ameliorated insulin resistance in obese mice. Our results indicated that BSP could be exploited as prebiotic to protect against obesity and insulin resistance in obese individuals.