Amyotrophic lateral sclerosis with sensory neuropathy: part of a multisystem disorder?. Issue 7 (15th June 2007)

• Record Type: Journal Article
• Authors: Isaacs, Jeremy D; Dean, Andrew F; Shaw, Christopher E; Al-Chalabi, Ammar; Mills, Kerry R; Leigh, P Nigel
• Is Part Of: Journal of neurology, neurosurgery and psychiatry. Volume 78:Issue 7(2007)
• Page Start: 750
• Page End: 753
• Publication Date: 2007-06-15
• Subjects: ALS, amyotrophic lateral sclerosis -- MGUS, monoclonal gammopathy of unknown significance -- SAP, sensory action potential; Neurology -- Periodicals; Nervous system -- Surgery -- Periodicals; Psychiatry -- Periodicals; 616.8
• DOI: 10.1136/jnnp.2006.098798
• Languages: English
• ISSNs: 0022-3050

Abstract

Abstract : Sensory involvement is thought not to be a feature of amyotrophic lateral sclerosis (ALS). However, in the setting of a specialist motor neuron disease clinic, we have identified five patients with sporadic ALS and a sensory neuropathy for which an alternative cause could not be identified. In three individuals, sensory nerve biopsy was performed, demonstrating axonal loss without features of an alternative aetiology. These findings support the hypothesis that ALS is a multisystem neurodegenerative disorder that may occasionally include sensory neuropathy among its non-motor features.