Innate Immune Response to Adenovirus. (1st September 2005)

• Record Type: Journal Article
• Authors: Nazir, Shoab A.; Metcalf, Jordan P.
• Is Part Of: Journal of investigative medicine. Volume 53:Number 6(2005)
• Page Start: 292
• Page End: 304
• Publication Date: 2005-09-01
• Subjects: adenovirus -- innate immunity -- cytokines; Clinical medicine -- Periodicals; Medicine -- Research -- Periodicals; Medicine; Research -- United States; Clinical medicine; Medicine -- Research; Periodicals; 616.075
• DOI: 10.2310/6650.2005.53605
• Languages: English
• ISSNs: 1081-5589

Abstract

Abstract : ABSTRACT: Adenovirus is a common infectious pathogen in both children and adults. It is a significant cause of morbidity in immunocompetent people living in crowded living conditions and of mortality in immunocompromised hosts. It has more recently become a popular vehicle for gene therapy applications. The host response to wild-type infection and gene therapy vector exposure involves both the innate and adaptive immune systems. The initial innate immune response is associated with the severe acute manifestations of adenovirus infection and also plays a significant role in acute toxicity owing to adenovirus vector exposure. This review discusses the innate immune response primarily during wild-type adenovirus infection because this serves as the basis for understanding the response during both natural infection and exposure to adenovirus vectors.