Relevance of the natural HDAC inhibitor sulforaphane as a chemopreventive agent in urologic tumors. (28th October 2018)

• Record Type: Journal Article
• Authors: Juengel, Eva; Erb, Holger H.H.; Haferkamp, Axel; Rutz, Jochen; Chun, Felix K.-H.; Blaheta, Roman A.
• Is Part Of: Cancer letters. Volume 435(2018)
• Page Start: 121
• Page End: 126
• Publication Date: 2018-10-28
• Subjects: Sulphoraphane -- Dietary HDAC inhibitor -- Chemoprevention -- Urologic tumors; Cancer -- Periodicals; Neoplasms -- Periodicals; Cancer -- Périodiques; Electronic journals; 616.994
• DOI: 10.1016/j.canlet.2018.07.017
• Languages: English
• ISSNs: 0304-3835

Abstract

Abstract: Due to an increased understanding of molecular biology and the genomics of cancer, new and potent agents have been approved by the Food and Drug Administration (FDA) to fight this disease. However, all of these drugs cause severe side effects and resistance inevitably develops, re-activating tumor growth and dissemination. For this reason, patients turn to natural compounds as alternative or complementary treatment options, since it has been found that natural plant products may block, inhibit, or reverse cancer development. The present review focusses on the role of the natural compound sulforaphane (SFN) as an anti-tumor agent in urologic cancer. SFN is a natural compound found in cruciferous vegetables from the Brassicaceae family such as broccoli, cauliflower and cabbage. Several epidemiologic and clinical studies have documented chemopreventive properties of SFN, making it an interesting candidate for additive cancer treatment. SFN shows remarkable anti-tumor effects in vitro and in vivo without exerting toxicity. The review summarizes the current understanding of SFN and provides insights into its molecular mode of action with particular emphasis on epigenetic tumor control. Highlights: Sulforaphane is found in cruciferous vegetables such as broccoli, cauliflower and cabbage. Sulforaphane exerts potential chemopreventive properties. Sulforaphane attenuates tumor growth, metastasis and angiogenesis in vitro and in vivo. Sulforaphane alters acetylation of histones and modifies intracellular signaling. Sulforaphane might be a valuable additive for future anti-tumor protocols.