Changes of brain DTI in healthy human subjects after 520 days isolation and confinement on a simulated mission to Mars. (February 2020)

• Record Type: Journal Article
• Authors: Brem, Christian; Lutz, Jürgen; Vollmar, Christian; Feuerecker, Matthias; Strewe, Claudia; Nichiporuk, Igor; Vassilieva, Galina; Schelling, Gustav; Choukér, Alexander
• Is Part Of: Life sciences in space research. Volume 24(2020)
• Page Start: 83
• Page End: 90
• Publication Date: 2020-02
• Subjects: Myelin plasticity -- Confinement -- MARS500 -- Isolation -- Personality traits; DTI Diffusion Tensor Imaging -- FA fractional anisotropy -- MD mean diffusivity, RD, radial diffusivity -- AD axial diffusivity -- ESA European Space Agency; Space biology -- Periodicals; 571.0919
• DOI: 10.1016/j.lssr.2019.09.004
• Languages: English
• ISSNs: 2214-5524

Abstract

Abstract: Introduction: Long-term confinement is known to be a stressful experience with multiple psycho-physiological effects. In the MARS500 project, a real-time simulation of a space-flight to Mars conducted in a hermetically isolated habitat, effects of long-term confinement could be investigated in a unique manner. The aim of this study was to evaluate effects of long-term-confinement on brain cytoarchitecture. Material & Methods: The participants of the MARS500 project underwent 3T-MR imaging including a dedicated DTI-sequence before the isolation, right after ending of confinement and 6 months after the experiment. Voxelwise statistical analysis of the DTI data was carried out using tract-based-spatial statistics, comparing an age-matched control group. Results: At all three sessions, significant lower fractional anisotropy (FA) than in controls was found in the anterior parts of the callosal body of the participants. Furthermore, after ending of confinement a wide-spread FA reduction could be seen in the right hemisphere culminating in the temporo-parietal-junction-zone. All these areas with decreased FA predominantly showed an elevated radial diffusivity and mean diffusivity while axial diffusivity was less correlated. Discussion: Long-term confinement does have measurable effects on the microstructure of the brain white matter. We assume effects of sensory deprivation to account for the regional FA reductions seen in the right TPJ. The differences in the Corpus callosum were interpreted as due to preliminary conditions, e.g. personality traits or training effects. FA and radial diffusivity were the predominant DTI parameters with significant changes, suggesting underlying processes of myelin plasticity.