Co-solvence phenomenon and thermodynamic properties of edaravone in pure and mixed solvents. (November 2019)

• Record Type: Journal Article
• Authors: Li, Rongrong; Yao, Lusha; Khan, Arshad; Zhao, Bo; Wang, Dehua; Zhao, Jia; Han, Deman
• Is Part Of: Journal of chemical thermodynamics. Volume 138(2019)
• Page Start: 304
• Page End: 312
• Publication Date: 2019-11
• Subjects: Edaravone -- Solubility -- Solubility parameter -- Thermodynamic properties; Thermodynamics -- Periodicals; Thermochemistry -- Periodicals; Thermodynamique -- Périodiques; Thermochimie -- Périodiques; Thermochemistry; Thermodynamics; Periodicals; 541.369
• DOI: 10.1016/j.jct.2019.06.018
• Languages: English
• ISSNs: 0021-9614

Abstract

Graphical abstract: Highlights: Research the solubility of edaravone in pure and mixed solvents. Extended Hildebrand Solubility Approach was applied to explain co-solvence phenomenon. The solubility data were correlated by some thermodynamic models. Some apparent thermodynamic properties were evaluated. Abstract: The dissolution behavior of drugs in cosolvent mixtures is very important, especially in systems with co-solvence phenomenon. The solubility of edaravone in pure and mixed solvents was determined experimentally by using the isothermal dissolution equilibrium method within the temperature range from (273.15 to 313.15) K under atmosphere pressure (101.3 kPa). The maximum solubility was (4.72 × 10 −2 in mole fraction) obtained at 313.15 K in n -propanol, and the minimum data was found at 273.15 K in acetonitrile. However, in mixed solvents, the solubility of edaravone increased with the increasing temperature, while increased with increasing co-solvent mass fraction ( w ) to a maximum value at w = 0.6 and then decreased, and Extended Hildebrand Solubility Approach was applied to explain this phenomenon. In addition, the solubility data obtained were correlated with the modified Apelblat equation, λh equation, Jouyban-Acree model and CNIBS/R-K model. The results indicated that the modified apelblat equation and Jouyban-Acree model are more suitable to correlate solubility data of edaravone in studied pure and mixed solvents, respectively. The apparent dissolution standard enthalpy ( Δ H sol o ), apparent molar standard Gibbs energy ( Δ G sol o ) and Δ S sol o of edaravone in pure and mixed solvents were also evaluated.