Phenytoin-induced increase in growth hormone response to levodopa in adult males. Issue 7 (July 1984)

• Record Type: Journal Article
• Authors: D'Alessandro, R; Cortelli, P; Gallassi, R; Ghisoli, E; Montanaro, N; Zoni, E; Baruzzi, A
• Is Part Of: Journal of neurology, neurosurgery and psychiatry. Volume 47:Issue 7(1984)
• Page Start: 715
• Page End: 719
• Publication Date: 1984-07
• Subjects: Neurology -- Periodicals; Nervous system -- Surgery -- Periodicals; Psychiatry -- Periodicals; 616.8
• DOI: 10.1136/jnnp.47.7.715
• Languages: English
• ISSNs: 0022-3050

Abstract

Abstract : Growth hormone and prolactin response to levodopa were evaluated before and after long-term phenytoin treatment in five men with previously untreated partial epilepsy. After phenytoin treatment, growth hormone response to levodopa increased. There was a close relationship between growth hormone response to levodopa and plasma phenytoin concentrations. These findings suggest a phenytoin-induced dopaminergic activity at the hypothalamic-pituitary level in adult males.