Pure akinesia: an atypical manifestation of progressive supranuclear palsy. Issue 5 (May 1991)

• Record Type: Journal Article
• Authors: Matsuo, H; Takashima, H; Kishikawa, M; Kinoshita, I; Mori, M; Tsujihata, M; Nagataki, S
• Is Part Of: Journal of neurology, neurosurgery and psychiatry. Volume 54:Issue 5(1991)
• Page Start: 397
• Page End: 400
• Publication Date: 1991-05
• Subjects: Neurology -- Periodicals; Nervous system -- Surgery -- Periodicals; Psychiatry -- Periodicals; 616.8
• DOI: 10.1136/jnnp.54.5.397
• Languages: English
• ISSNs: 0022-3050

Abstract

Abstract : Two patients with "pure akinesia" who showed the characteristic changes of progressive supranuclear palsy (PSP) at necropsy are described. They had akinesia but no rigidity or tremor, and ophthalmoplegia was not observed during the course of illness. The symptoms of "pure akinesia" was not improved by levodopa therapy but was considerably improved by L-threo-3, 4-dihydroxy-phenylserine. At necropsy, pathological findings were not different from those reported for PSP. It is suggested that "pure akinesia" is an atypical manifestation of PSP, and that norepinephrinergic neurons may be involved in some types of PSP.