5, 10-methylenetetrahydrofolate reductase (MTHFR) 677C→T and 1298A→C mutations are associated with DNA hypomethylation. Issue 6 (1st June 2004) - Castro, R; Rivera, I; Ravasco, P; Camilo, M E; Jakobs, C; Blom, H J; de Almeida, I T