Manganese in long term paediatric parenteral nutrition. Issue 6 (December 1994)

• Record Type: Journal Article
• Authors: Reynolds, A P; Kiely, E; Meadows, N
• Is Part Of: Archives of disease in childhood. Volume 71:Issue 6(1994)
• Page Start: 527
• Page End: 528
• Publication Date: 1994-12
• Subjects: Children -- Diseases -- Periodicals; Infants -- Diseases -- Periodicals; 618.920005
• DOI: 10.1136/adc.71.6.527
• Languages: English
• ISSNs: 0003-9888

Abstract

Abstract : The current practice of providing manganese supplementation to neonates on long term parenteral nutrition is leading to a high incidence of hypermanganesaemia. Magnetic resonance imaging (MRI) studies in adults on long term manganese parenteral nutrition have shown changes in TI weighted MRI images and similar findings in a neonate receiving trace element supplementation are reported here. Whole blood manganese concentration in the infant was 1740 nmol/l (or 8.3 times upper reference limit). In all neonates on long term parenteral nutrition with evidence of cholestatic liver disease so far investigated, the whole blood manganese concentrations were > 360 nmol/l (reference range 73-210). Manganese supplementation to patients on long term parenteral nutrition requires reappraisal, particularly in those who develop cholestatic liver disease associated with parenteral nutrition.