Cytomegalic Inclusion Disease caused by Cytomegalovirus Infection in the Salivary Glands of an African Hedgehog (Atelerix arbiventris). Issue 4 (November 2017)

• Record Type: Journal Article
• Authors: Koyama, K.; Horiuchi, N.; Hasegawa, H.; Katano, H.; Oohashi, E.; Watanabe, K.; Kobayashi, Y.
• Is Part Of: Journal of comparative pathology. Volume 157:Issue 4(2017)
• Page Start: 299
• Page End: 302
• Publication Date: 2017-11
• Subjects: African hedgehog -- cytomegalic inclusion disease -- cytomegalovirus -- salivary gland; Veterinary pathology -- Periodicals; Veterinary therapeutics -- Periodicals; Pathology, Comparative -- Periodicals; Therapeutics -- Periodicals; Pathology, Veterinary -- Periodicals; 636.089607
• DOI: 10.1016/j.jcpa.2017.09.006
• Languages: English
• ISSNs: 0021-9975

Abstract

Summary: Cytomegalic inclusion disease (CID) in the salivary gland of African hedgehogs ( Atelerix arbiventris ) has been reported before, and is suspected to reflect a cytomegalovirus infection. However, a recent ultrastructural study reported that African hedgehog CID reflected oncocytic metaplasia, mimicking a cytomegalovirus infection. We examined the submandibular and sublingual salivary glands of a 1-year-old male African hedgehog. Histologically, there were multiple foci composed of cytomegalic cells with intranuclear inclusion bodies. Ultrastructurally, viral particles (109–118 nm in diameter) were observed in the nuclei of the cytomegalic cells. There were numerous vesicles containing various numbers of enveloped viruses in the cytoplasm. We also attempted to detect viral DNA fragments by degenerate polymerase chain reaction and obtained amplicons of a predicted size. Phylogenetic analysis indicated that the virus is a betaherpesvirus, comparatively related to human and rodent cytomegaloviruses. The present study suggested that African hedgehog CIDs also include those caused by the cytomegalovirus.