Advanced glycation end products (AGEs) in oral pathology. (September 2018)

• Record Type: Journal Article
• Authors: Ilea, Aranka; Băbţan, Anida M.; Boşca, Bianca A.; Crişan, Maria; Petrescu, Nausica B.; Collino, Massimo; Sainz, Rosa M.; Gerlach, Jared Q.; Câmpian, Radu Septimiu
• Is Part Of: Archives of oral biology. Volume 93(2018)
• Page Start: 22
• Page End: 30
• Publication Date: 2018-09
• Subjects: Advanced glycation end products - AGEs -- Chronic inflammation -- Diet-related disease -- Oral pathology -- Salivary biosensor; Mouth -- Periodicals; Mouth -- Diseases -- Periodicals; Dentistry -- Periodicals; Electronic journals; 617.6005
• DOI: 10.1016/j.archoralbio.2018.05.013
• Languages: English
• ISSNs: 0003-9969

Abstract

Highlights: AGEs accumulate in tissues and induce subclinical inflammation. AGEs' accumulation increases the risk for general and oral pathologies. AGEs can be identified and quantified in the oral tissues and biological fluids. Salivary AGEs could be used as biomarker for the diet-related diseases. Abstract: Objective: Maillard advanced glycation end products (AGEs) are connected with high dry temperature food processing, color and flavor modification of food products. Oral cavity pathology is strongly influenced by dietary intake. The aim of the present paper is to update current data regarding the sources and metabolism of AGEs, their impact on oral cavity tissues, to discuss and suggest new approaches for the early diagnosis and efficient treatment of AGEs-related oral pathology. Design: This paper is a narrative review of the studies discussing AGEs and mainly the dietary AGEs (dAGEs) sources, metabolism, linkage to general diseases, and specifically the oral cavity pathology. The authors used "PUBMED" and MeSH for the finding of English written and published articles concerning AGEs. There were used the next keywords association: "advanced glycation end products- AGEs" AND "Maillard products", "AGEs" AND "diet-related disease, "AGEs" AND "salivary biosensor", "AGEs" AND "metabolic syndrome AGEs", "AGEs" AND "oral pathology", "AGEs" AND "dentin AGEs" OR "periodontal AGEs", "AGEs" AND "diagnosis and monitoring". The authors used free full-text articles to determine the etiology and physiopathology of AGEs, their association with general diseases and oral cavity disease, assessment methods used in biofluids and tissues, AGEs prevention and treatment approaches. Articles concerning AGEs etiology, metabolism and effect in the human body and specific implication in oral pathology were selected. There were no exclusion criteria in what concerns the study design. Studies in other language than English and articles abstracts were excluded. Criteria of inclusion were free full-text articles written in English. Equally human and animal model studies were included. Regarding the date of publication, all subjects concerning glycation products after 1953 (first published article) were included. Results: Evidence show that AGEs are responsible for inducing low intensity chronic inflammation and thereby, for initiating and/or aggravating chronic diseases. Nowadays, research has demonstrated a significant association between AGEs and dental or periodontal pathology. Moreover, salivary AGEs are consistent with the levels of AGEs in other biological fluids and are correlated with the general and oral pathology. Conclusions: Assessment of salivary AGEs could be a reliable tool for early diagnosis and monitoring diet-related disease.