Room temperature dehalogenation of (hetero)aryl halides with magnesium/methanol. Issue 32 (8th August 2018)

• Record Type: Journal Article
• Authors: Jouha, Jabrane; Khouili, Mostafa; Hiebel, Marie-Aude; Guillaumet, Gérald; Suzenet, Franck
• Is Part Of: Tetrahedron letters. Volume 59:Issue 32(2018)
• Page Start: 3108
• Page End: 3111
• Publication Date: 2018-08-08
• Subjects: Dehalogenation -- Magnesium -- Methanol -- Dehalogenation -- Heteroaryl halides -- Aryl halides; Chemistry, Organic -- Periodicals; 547.005
• DOI: 10.1016/j.tetlet.2018.07.008
• Languages: English
• ISSNs: 0040-4039

Abstract

Graphical abstract: Highlights: (Hetero)aryl halides are efficiently dehalogenated with magnesium in methanol. Various functional groups are tolerated under mild conditions. Iodo-, bromo- and chloro-derivatives are good substrates. This dehalogenation method represents a trustworthy alternative to other approaches already reported. Abstract: Magnesium in methanol was found to be an effective and inexpensive reagent for the dehalogenation of (hetero)aryl chlorides, bromides and iodides under mild conditions. The halogen/hydrogen exchange proceeded at room temperature and tolerated functional groups such as esters, nitriles, alcohols, and alkenes.