Increased Expression of Dachshund Homolog 1 in Ovarian Cancer as a Predictor for Poor Outcome. Issue 3 (1st March 2012)

• Record Type: Journal Article
• Authors: Liang, Fei; Lü, Qingtao; Sun, Shuyu; Zhou, Jie; Popov, Vladimir M.; Li, Shaoru; Li, Weihua; Liu, Yang; Jiang, Jie; Kong, Beihua
• Is Part Of: International journal of gynecological cancer. Volume 22:Issue 3(2012)
• Page Start: 386
• Page End: 393
• Publication Date: 2012-03-01
• Subjects: Dachshund homolog 1 -- Ovarian cancer -- Estrogen receptor -- Metastasis; Generative organs, Female -- Cancer -- Periodicals; 616.99465
• DOI: 10.1097/IGC.0b013e31824311e6
• Languages: English
• ISSNs: 1048-891X

Abstract

Abstract : Objective: This study aimed to determine the functional relationship between the levels of dachshund homolog 1 (DACH1) expression and different subtypes of ovarian cancer and to investigate the possible prognostic value of DACH1 in ovarian cancer. Methods: Immunohistochemical staining was deployed to determine the protein levels of DACH1. Staining was performed on patient samples, for whom the detailed follow-up data have been acquired during the last 10 years. Normal, benign, borderline, cancer, and metastatic ovarian cancer samples were included in this study. Results: The results of our study show that DACH1 protein levels increase with the invasiveness of the ovarian cancer. As the cancer progresses from benign and borderline to metastatic, DACH1 protein expression increases as well. Moreover, with the increase in expression, the subcellular distribution of DACH1 changes from nucleus in normal tissue to cytoplasm in cancer. Finally, DACH1 expression levels were compared with estrogen receptor α (ERα) levels, and the results showed that overall DACH1 levels were higher, whereas also DACH1 exhibited increased cytoplasmic expression in ERα-positive ovarian cancer samples. Conclusions: These results indicate that DACH1 is highly expressed in metastatic ovarian cancer compared with that of normal, benign, and borderline ovarian tissues and that it could play an important role in cancer growth.