Interaction of α- and δβ0-thalassaemia: haematological features and globin chain synthesis analysis. Issue 1 (February 1981)

• Record Type: Journal Article
• Authors: Galanello, R; Furbetta, M; Melis, M A; Rosatelli, C; Cao, A
• Is Part Of: Journal of medical genetics. Volume 18:Issue 1(1981)
• Page Start: 40
• Page End: 42
• Publication Date: 1981-02
• Subjects: Medical genetics -- Periodicals; 616.042
• DOI: 10.1136/jmg.18.1.40
• Languages: English
• ISSNs: 1468-6244

Abstract

Abstract : An observation of suspected interaction of δβ 0 - and α-thalassaemia, identified through careful examination of the family, is reported. The δβ 0 -thalassaemia was of the usual type found in Sardinia, characterised by high Hb F levels and very low levels of glycine in the isolated γCB3 peptide. The haematological findings in the double δβ 0 -/α-thalassaemia heterozygotes were: normal MCV and Hb A2 levels, increased Hb F (11·3 to 16·8%) heterogeneously distributed in red cells, and almost balanced α/β globin chain synthesis ratios.