Mapping of the X linked form of hyper IgM syndrome (HIGM1). Issue 3 (March 1993)

• Record Type: Journal Article
• Authors: Padayachee, M; Levinsky, R J; Kinnon, C; Finn, A; McKeown, C; Feighery, C; Notarangelo, L D; Hendriks, R W; Read, A P; Malcolm, S
• Is Part Of: Journal of medical genetics. Volume 30:Issue 3(1993)
• Page Start: 202
• Page End: 205
• Publication Date: 1993-03
• Subjects: Medical genetics -- Periodicals; 616.042
• DOI: 10.1136/jmg.30.3.202
• Languages: English
• ISSNs: 1468-6244

Abstract

Abstract : X linked immunodeficiency with hyperimmunoglobulinaemia M (HIGM1), which is characterised by agammaglobulinaemia together with excess IgM production reflecting an impairment of the immunoglobulin heavy chain class switch of B lymphocytes, has been mapped to Xq26. We report multipoint linkage data in six families with HIGM1 which show that the most likely position for the gene is close to HPRT with a maximum lod score of 4.89. The finding of recombinations between HIGM1 and both HPRT and DXS42 implies that HIGM1 is not allelic to X linked lymphoproliferative disease. These data will be useful in genetic counselling in families and will also be useful in testing candidate genes.