Carbon dot capped gold nanoflowers for electrochemiluminescent aptasensor of thrombin. (February 2018)

• Record Type: Journal Article
• Authors: You, Xu; Lin, Wei; Wu, Huan; Dong, Yongqiang; Chi, Yuwu
• Is Part Of: Carbon. Volume 127(2018)
• Page Start: 653
• Page End: 657
• Publication Date: 2018-02
• Subjects: Carbon -- Periodicals; Carbone -- Périodiques; Koolstof; Toepassingen; Electronic journals; 546.681
• DOI: 10.1016/j.carbon.2017.11.024
• Languages: English
• ISSNs: 0008-6223

Abstract

Abstract: A simple method has been developed to synthesize carbon dot capped gold nanoflower (CD/AuNF) nanohybrids. In principle, anodic electrochemiluminescent (ECL) carbon dots (CDs) with a lot of reductive functional groups were used to react with oxidative hydrogen tetrachloroaurate trihydrate in the presence of trisodium citrate. The obtained globular CD/AuNF nanohybrids had uniform sizes of 50–60 nm. The CD/AuNF nanohybrids were composed of gold nanoparticle aggregates in the centers and CDs on the surfaces. The easy self-assembly with some bio-molecules of AuNFs and the unique ECL activities of the CDs, made the obtained CD/AuNF nanohybrids promising in biosensing. For instance, a novel ECL aptasensor for thrombin (TB) detection has been developed based on the CD/AuNF nanohybrids. The aptasensor showed good selectivity towards TB. Furthermore, it presented a wide linear response range from 0.5 nM to 40 nM and a low detection limit (S/N = 3) of 0.08 nM. Graphical abstract: A simple method has been developed to synthesize carbon dot/gold nanoflower (CD/AuNF) nanohybrids, which were further applied in a novel ECL aptasensor of thrombin detection. Image 1