Tissue-engineered 3D models for elucidating primary and metastatic bone cancer progression. (November 2019)

• Record Type: Journal Article
• Authors: González Díaz, Eva C.; Sinha, Sauradeep; Avedian, Raffi S.; Yang, Fan
• Is Part Of: Acta biomaterialia. Volume 99(2019)
• Page Start: 18
• Page End: 32
• Publication Date: 2019-11
• Subjects: BMP Bone Morphogenetic Protein -- BSP Bone Sialoprotein -- CXCL12 C-X-C Motif Chemokine Ligand 12 -- CXCL5 C-X-C Motif Chemokine Ligand 5 -- CXCR2 C-X-C Motif Chemokine Receptor 2 -- CXCR4 C-X-C Motif Chemokine Receptor 4 -- CXCR7 C-X-C Motif Chemokine Receptor 7 -- FLI1 Friend Leukemia Integration 1 -- FGF Fibroblast Growth Factor -- HIF Hypoxia-Inducible Factor -- IGF-1 Insulin-Like Growth Factor 1 -- IGF-1R Insulin-Like Growth Factor Receptor 1 -- IL-6 Interleukin 6 -- IL-8 Interleukin 8 -- IL-11 Interleukin 11 -- MMP Matrix Metalloproteinase -- mTOR Mammalian Target of Rapamycin -- OPN Osteopontin -- PTH-rP Parathyroid Hormone-Related Protein -- RANKL Receptor Activator of Nuclear Factor Kappa-B Ligand -- RUNX2 Runt-Related Transcription Factor 2 -- Stat3 Signal Transducer and Activator of Transcription 3 -- TGF-β Transforming Growth Factor Beta -- TRAP Tartrate-Resistant Acid Phosphatase -- VEGF Vascular Endothelial Growth Factor -- YY1 Yin Yang 1; Tissue engineering -- Biomaterials -- Bone cancer -- Bone metastasis; Biomedical materials -- Periodicals; 610.28
• DOI: 10.1016/j.actbio.2019.08.020
• Languages: English
• ISSNs: 1742-7061

Abstract

Graphical abstract: Abstract: Malignant bone tumors are aggressive neoplasms which arise from bone tissue or as a result of metastasis. The most prevalent types of cancer, such as breast, prostate, and lung cancer, all preferentially metastasize to bone, yet the role of the bone niche in promoting cancer progression remains poorly understood. Tissue engineering has the potential to bridge this knowledge gap by providing 3D in vitro systems that can be specifically designed to mimic key properties of the bone niche in a more physiologically relevant context than standard 2D culture. Elucidating the crucial components of the bone niche that recruit metastatic cells, support tumor growth, and promote cancer-induced destruction of bone tissue would support efforts for preventing and treating these devastating malignancies. In this review, we summarize recent efforts focused on developing in vitro 3D models of primary bone cancer and bone metastasis using tissue engineering approaches. Such 3D in vitro models can enable the identification of effective therapeutic targets and facilitate high-throughput drug screening to effectively treat bone cancers. Statement of Significance: Biomaterials-based 3D culture have been traditionally used for tissue regeneration. Recent research harnessed biomaterials to create 3D in vitro cancer models, with demonstrated advantages over conventional 2D culture in recapitulating tumor progression and drug response in vivo. However, previous work has been largely limited to modeling soft tissue cancer, such as breast cancer and brain cancer. Unlike soft tissues, bone is characterized with high stiffness and mineral content. Primary bone cancer affects mostly children with poor treatment outcomes, and bone is the most common site of cancer metastasis. Here we summarize emerging efforts on engineering 3D bone cancer models using tissue engineering approaches, and future directions needed to further advance this relatively new research area.