Identification of patients with gout: elaboration of a questionnaire for epidemiological studies. Issue 9 (5th May 2014)

• Record Type: Journal Article
• Authors: Richette, P; Clerson, P; Bouée, S; Chalès, G; Doherty, M; Flipo, R M; Lambert, C; Lioté, F; Poiraud, T; Schaeverbeke, T; Bardin, T
• Other Names: Perez Vincent author non-byline.; Larzabal Dominique author non-byline.; Palestro Brigitte author non-byline.; Perissin Laure author non-byline.; Chevalier Xavier author non-byline.; Poursac Nicolas author non-byline.; Mehsen Nadia author non-byline.; Richez Christophe author non-byline.; Ravaud Philippe author non-byline.; Pascart Tristan author non-byline.; Ottaviani Sébastien author non-byline.; Sordet Christelle author non-byline.; Rouil Alban author non-byline.; Peyr Olivier author non-byline.; Rosenberg Sylvie author non-byline.; Corondan Anca author non-byline.; Semerano Luca author non-byline.; Zylberman-Yona Hagit author non-byline.; Mammou Saloua author non-byline.; Cesini Johann author non-byline.; Kozyreff-Meurice Marie author non-byline.; Gamon Etienne author non-byline.
• Is Part Of: Annals of the rheumatic diseases. Volume 74:Issue 9(2015)
• Page Start: 1684
• Page End: 1690
• Publication Date: 2014-05-05
• Subjects: Rheumatism -- Periodicals; 616.723005
• DOI: 10.1136/annrheumdis-2013-204976
• Languages: English
• ISSNs: 0003-4967

Abstract

Abstract : Objectives: In France, the prevalence of gout is currently unknown. We aimed to design a questionnaire to detect gout that would be suitable for use in a telephone survey by non-physicians and assessed its performance. Methods: We designed a 62-item questionnaire covering comorbidities, clinical features and treatment of gout. In a case–control study, we enrolled patients with a history of arthritis who had undergone arthrocentesis for synovial fluid analysis and crystal detection. Cases were patients with crystal-proven gout and controls were patients who had arthritis and effusion with no monosodium urate crystals in synovial fluid. The questionnaire was administered by phone to cases and controls by non-physicians who were unaware of the patient diagnosis. Logistic regression analysis and classification and regression trees were used to select items discriminating cases and controls. Results: We interviewed 246 patients (102 cases and 142 controls). Two logistic regression models (sensitivity 88.0% and 87.5%; specificity 93.0% and 89.8%, respectively) and one classification and regression tree model (sensitivity 81.4%, specificity 93.7%) revealed 11 informative items that allowed for classifying 90.0%, 88.8% and 88.5% of patients, respectively. Conclusions: We developed a questionnaire to detect gout containing 11 items that is fast and suitable for use in a telephone survey by non-physicians. The questionnaire demonstrated good properties for discriminating patients with and without gout. It will be administered in a large sample of the general population to estimate the prevalence of gout in France.