Evaluating antirheumatic treatments using synovial biopsy: a recommendation for standardisation to be used in clinical trials. Issue 3 (24th November 2010)

• Record Type: Journal Article
• Authors: van de Sande, Marleen G H; Gerlag, Danielle M; Lodde, Beatrijs M; van Baarsen, Lisa G M; Alivernini, Stefano; Codullo, Veronica; Felea, Ioana; Vieira-Sousa, Elsa; Fearon, Ursula; Reece, Richard; Montecucco, Carlomaurizio; Veale, Douglas J; Pitzalis, Costantino; Emery, Paul; Klareskog, Lars; McInnes, Iain B; Tak, Paul P
• Is Part Of: Annals of the rheumatic diseases. Volume 70:Issue 3(2011)
• Page Start: 423
• Page End: 427
• Publication Date: 2010-11-24
• Subjects: Rheumatism -- Periodicals; 616.723005
• DOI: 10.1136/ard.2010.139550
• Languages: English
• ISSNs: 0003-4967

Abstract

Abstract : Inflammation of synovium is one of the hallmarks of rheumatoid arthritis (RA). Analysis of synovial tissue has increased our understanding of RA pathogenesis, aided in identifying potential therapeutic targets and has been used in the response and mechanistic evaluation of antirheumatic treatments. In addition, studies are ongoing, aimed at the identification of diagnostic and prognostic biomarkers in the synovium. This paper outlines the currently used procedures for sampling and processing of synovial tissue, and presents a standardised recommendation to support multicentre translational research.