Risk factors of post-surgery complications in children with thyroid cancer. (December 2019)

• Record Type: Journal Article
• Authors: Babala, Jozef; Zahradníková, Petra; Béder, Igor; Fedorová, Lenka; Lindák, Martin; Košťálová, Ľudmila; Pribilincová, Zuzana; Staník, Juraj; Králik, Róbert
• Is Part Of: International journal of pediatric otorhinolaryngology. Volume 127(2019:Dec.)
• Publication Date: 2019-12
• Subjects: Thyroid cancer -- Thyroid surgery -- Thyroidectomy; Otolaryngology -- Periodicals; Pediatrics -- Periodicals; Otolaryngology -- Periodicals; Pediatrics -- Periodicals; Oto-rhino-laryngologie -- Périodiques; Pédiatrie -- Périodiques; 618.9209751
• DOI: 10.1016/j.ijporl.2019.109673
• Languages: English
• ISSNs: 0165-5876

Abstract

Abstract: Introduction: Thyroid cancer in children is a hot topic because of the large clinical heterogeneity and the risk of severe complications. We aimed to study 1. The frequency, 2. Etiology, and 3. Risk factors of post-surgery complications of thyroid cancer. Material and methods: A retrospective analysis including risk factors for post-surgery complications of patients treated for thyroid malignancies in years 2006–2018 was performed. Results: Over a period of 12 years 22 patients with thyroid malignancy (68% female; 12.6 ± 4.0 years of age, median follow-up 6 years) were identified. Histologically, 12 (55%) patients had papillary carcinoma. Six patients (27.3%) had multiple endocrine neoplasia type 2 (MEN2) syndrome, 3 (13.7%) patients had medullary carcinoma and 1 patient had follicular carcinoma. Neck lymph node metastases were diagnosed in 8 (36.4%), distant metastases in 6 (27.3%), and both locations were involved in 4 (18.2%) patients. Six (27.3%) children had surgical complications: 1 child had unilateral vocal cord paralysis and transient hypoparathyroidism and 5 had transient hypoparathyroidism. The higher risk of surgery complications in forward stepwise logistic regression was associated in with distant metastases (R2 = 0.584, OR 52.63, p = 0.010). Conclusions: Postoperative complications were significantly associated with presence of distant metastases. Favorable results were observed in with children with MEN2 syndrome.