AB0165 Association between neutrophil to lymhocyte ratio with disase activity in rheumatoid arthritis and ankylosing spondylitis. (23rd January 2014)

• Record Type: Journal Article
• Authors: Mercan, R.; Tufan, A.; Bitik, B.; Tezcan, M. E.; Kaya, A.; Goker, B.; Ozturk, M. A.; Haznedaroglu, S.
• Is Part Of: Annals of the rheumatic diseases. Volume 72:Supplement 3(2013)
• Page Start: A836
• Page End: A836
• Publication Date: 2014-01-23
• Subjects: Rheumatism -- Periodicals; 616.723005
• DOI: 10.1136/annrheumdis-2013-eular.2488
• Languages: English
• ISSNs: 0003-4967

Abstract

Abstract : Background: Blood neutrophil-to-lymphocyte ratio (NLR) is a new inflammatory index which has been shown to be associated with prognosis of many disorders including cardiovascular diseases and neoplastic conditions. Its role in acute inflammation was also studied with a good discriminative value from those noninflammatory conditions. The value of NLR in the assessment of activity of inflammatory arthritides is not studied. Objectives: To investigate correlation of NLR with disease activity indices in patients with rheumatoid arthritis (RA) and ankylosing spondylitis (AS). Methods: One hundred eighteen RA (76% female, mean age 46.8±10.1 years) and 138 AS (43% female, mean age 36.7±9.3 years) patients were enrolled. Control group constituted 117 healthy subjects (34% female, mean age 36.1±12.0 years). Disease activities were evaluated with DAS28 and BASDAI indices in RA and AS patients, respectively. Hemoglobin, white blood cell (WBC) counts; erythrocyte sedimentation rate (ESR) and C reactive protein (CRP) levels were measured. WBC differential was obtained from complete blood counts. Results: RA and AS patients had remarkably higher ESR, CRP and WBC measurements and significantly lower hemoglobin levels compared to control subjects (p<0.001 for each parameter). NLR was significantly higher in RA patients compared to healthy subjects (2.59±1.2 vs 2.15±1.1, p=0.023). NLR is moderately correlated with DAS 28 and CRP in patients with RA (r:0.37 p=0.002, r:0.30 p<0.001, respectively). However NLR was not correlated with BASDAI in AS patients. Conclusions: NLR could be used as a marker of activity in patients with RA and showed a moderate correlation with DAS 28. However such a correlation was not observed in AS patients. Disclosure of Interest: None Declared