SAT0202 Early Accrual of Organ Damage in Systemic Sclerosis: Rationale for Forming a Multinational Inception Cohort of Patients with Scleroderma (The Insync Study). (23rd January 2014)

• Record Type: Journal Article
• Authors: Nikpour, M.; Baron, M.; Hudson, M.; Carreira, P.; Hunzelmann, N.; Frech, T.; Sahhar, J.; Nash, P.; Roddy, J.; Schrieber, L.; Stevens, W.; Proudman, S.
• Is Part Of: Annals of the rheumatic diseases. Volume 72:Supplement 3(2013)
• Page Start: A649
• Page End: A649
• Publication Date: 2014-01-23
• Subjects: Rheumatism -- Periodicals; 616.723005
• DOI: 10.1136/annrheumdis-2013-eular.1928
• Languages: English
• ISSNs: 0003-4967

Abstract

Abstract : Background: Systemic sclerosis (SSc) has the potential to result in irreversible damage in various organs. Objectives: To determine the accrual of damage in each organ system in the first five years of SSc disease. Methods: A panel of experts defined organ-specific indicators of damage in SSc. Using prospectively acquired data from patients entering the Australian Scleroderma Cohort Study within 2 years of disease onset, annual accrual of organ damage from years 2 to 5 following disease onset was determined. Results: The frequency of each damage indicator at years 2 to 5 in 182 patients is presented in the graph. Damage occurred in all organ systems, most commonly in the skin/MSK (23.1% at 4 years), respiratory (12.1%), GI (7.1%) & GU systems (erectile dysfunction in men 31.4%). Image/graph: Conclusions: Organ damage occurs early in SSc. This is a compelling rationale for forming a large inception cohort (INternational SYstemic Sclerosis Inception Cohort; INSYNC) of patients with SSc to determine the predictors of organ damage and to develop strategies for preventing the occurrence of organ damage in SSc. Disclosure of Interest: None Declared