Role of nitric oxide in the regulation of T cell functions. (12th October 2006)

• Record Type: Journal Article
• Authors: Niedbala, W; Cai, B; Liew, F Y
• Is Part Of: Annals of the rheumatic diseases. Volume 65(2006)Supplement 3
• Page Start: iii37
• Page End: iii40
• Publication Date: 2006-10-12
• Subjects: Ag, antigen -- cGMP, 3′, 5′-cyclic guanosine monophosphate -- IL-12R, interleukin-12 receptor -- iNOS, inducible nitric oxide synthase -- NOC-18, 2, 2′-(hydroxynitrosohydrazino)bis-ethamine -- ODQ, 1-H-oxodiazolo-(1, 2, 4)-(4, 3-a) guinoxaline-1-one -- sGC, soluble guanylyl cyclase -- TCR, T cell receptor -- Th, helper T cell -- Tc, cytotoxic T cell -- Tp, T cells precursor -- Treg, regulatory T cell; nitric oxide -- T cell functions -- regulation -- immunoregulation; Rheumatism -- Periodicals; 616.723005
• DOI: 10.1136/ard.2006.058446
• Languages: English
• ISSNs: 0003-4967

Abstract

Abstract : There is a close relation between T helper (Th) 1 cells and nitric oxide in disease. Thus it is possible that a reciprocal regulatory mechanism exists between them. This paper briefly describes the experimental studies which have helped elucidate the mechanism by which nitric oxide selectively enhances Th 1 cell proliferation and the potential effect of nitric oxide on regulatory T (Treg) cells. On the basis of the results the authors propose that nitric oxide represents an additional signal for the induction of T cell subset response, contributing to the increasingly complex network of immune regulation essential for health and disease.