Early expressed circulating long noncoding RNA CHAST is associated with cardiac contractile function in patients with acute myocardial infarction. (1st March 2020)

• Record Type: Journal Article
• Authors: Wang, Xuehui; Wang, Lei; Ma, Zhiyuan; Liang, Wanqian; Li, Jianhua; Li, Yan; Gui, Yingying; Ai, Sizhi
• Is Part Of: International journal of cardiology. Volume 302(2020)
• Page Start: 15
• Page End: 20
• Publication Date: 2020-03-01
• Subjects: AMI acute myocardial infarction -- lncRNAs long non-coding RNAs -- CHAST cardiac hypertrophy–associated transcript -- LIPCAR long intergenic non-coding RNA predicting cardiac remodeling -- LV left ventricular -- LVEF left ventricular ejection fraction -- LVFS left ventricular short axis shortening rate -- LVDD left ventricular end-diastolic volume -- PE phenylephrine -- ISO isoproterenol -- BNP brain natriuretic peptide -- ECG electrocardiogram -- NT-proBNP amino-terminal pro-brain natriuretic peptide -- CK-MB creatine kinase-muscle/brain -- cTnI cardiactroponin I -- Scr serum creatinine -- eGFR estimated glomerular filtration rate -- TC total cholesterol -- TG triglyceride -- LDL low density lipoprotein -- IQR interquartile range; Myocardial infarction -- Biological markers -- Long noncoding RNA -- Contractile function -- Cardiac remodeling; Cardiology -- Periodicals; Electronic journals; 616.12
• DOI: 10.1016/j.ijcard.2019.12.058
• Languages: English
• ISSNs: 0167-5273

Abstract

Abstract: Background: The mortality rate during the acute myocardial infarction (AMI) phase has substantially decreased, but post-AMI cardiac remodeling remains an important factor affecting patient prognosis. Several circulating long noncoding RNAs (lncRNAs) are reportedly involved in the chronic pathological process of cardiac function and remodeling in cardiovascular diseases. However, the potential roles of these circulating lncRNAs as biomarkers of cardiac function and remodeling during early-stage AMI remain unclear. Methods: Fifty-three patients with AMI and 90 controls without AMI were consecutively enrolled in this study. Clinical parameters and blood samples at different time points (i.e., 24 h and 3 days) were collected. Results: Compared with the controls, the circulating levels of cardiac hypertrophy-associated transcript (CHAST) significantly increased in AMI patients, and the CHAST levels obviously decreased at 3 days. In AMI patients, the expression levels of CHAST at 24 h were positively associated with cardiac contractile function and measured as left ventricular ejection fraction and left ventricular short-axis shortening rate (all P < 0.050). Multivariate regression analysis indicated that the expression level of CHAST at 24 h was an independent predictor of cardiac contractile function (standardized β = 0.319, P =0.034). When grouped according to the quartile values of the CHAST in the AMI population, patients with the highest quartiles of CHAST expression level showed better cardiac contractile function than all the other quartiles (all P < 0.050). Conclusion: CHAST was an independent predictor of cardiac contractile function at early-stage AMI and may serve as a candidate biomarker for cardiac remodeling. Highlights: Our study provided the first evidence that circulating levels of CHAST were significantly elevated at the early-stage of AMI. Circulating CHAST was an independent predictor of cardiac contractile function at early-stage AMI. CHAST may serve as a candidate biomarker for assessment of LV contractile function and remodeling at the early-stage of AMI.